Legionnaires' disease
Legionnaires' disease usually develops two to 14 days after exposure to the legionella bacteria. It frequently begins with the following signs and symptoms:

• Headache
• Muscle pain
• Chills
• Fever that may be 104 F (40 C) or higher

If you have Legionnaires' disease, by the second or third day, you'll develop other signs and symptoms that may include:

• Cough, which may bring up mucus and sometimes blood
• Shortness of breath
• Chest pain
• Fatigue
• Loss of appetite
• Gastrointestinal symptoms, such as nausea, vomiting and diarrhea
• Confusion or other mental changes

Although Legionnaires' disease primarily affects the lungs, it occasionally can cause infections in wounds and in other parts of the body, including the heart.

Pontiac fever
Pontiac fever is a mild form of Legionnaires' disease. It's marked by:

• Fever
• Chills
• Headache
• Muscle aches

Pontiac fever doesn't infect your lungs. If you have Pontiac fever, your symptoms will clear in about two to five days.

Unlike Legionnaire's disease, Pontiac fever has a short incubation period — usually two to three days — and affects people with no known risk factors for the illness. Some researchers speculate that Pontiac fever isn't an infection at all, but rather a hypersensitivity reaction to legionella bacteria or to the single-celled organisms (protozoa) in which they replicate.

When to see a doctor
See your doctor if you think you've been exposed to legionella bacteria. Be sure to mention any trips you've taken in the past two weeks and where you stayed. Diagnosing and treating Legionnaires' disease as soon as possible can help shorten the recovery period and prevent serious complications. For people at high risk, prompt treatment is critical.

©1998-2009 Mayo Foundation for Medical Education and Research (MFMER). Terms of use.

The bacterium Legionella pneumophila is responsible for most cases of Legionnaire's disease, although several other species of legionella also can cause infection. Legionella bacteria thrive in warm, damp environments. In nature, they can survive for months in lakes, rivers, hot springs and soil. But the levels of bacteria in the natural environment are so low that they rarely cause problems. The real threat is indoors, where legionella bacteria can multiply in water systems, whirlpool spas, air conditioning systems and even the misters in grocery store produce departments.

Like many microorganisms, legionella bacteria have the ability to anchor themselves to the interiors of pipes, faucets and shower heads. Once attached, the bacteria replicate in a sticky substance called a biofilm. As water flows past, it dislodges some of the biofilm, dispersing bacteria throughout the water system. Although it's possible to contract Legionnaires' disease from home plumbing systems, most outbreaks have occurred in large buildings, perhaps because complex systems allow the bacteria to grow and spread more easily.

How the infection spreads
Most people become infected when they inhale microscopic water droplets containing legionella bacteria. This might be the spray from a shower, faucet or whirlpool, or water dispersed through the ventilation system in a large building. Outbreaks have been linked to a range of sources, including:

• Whirlpool spas on cruise ships
• Cooling towers in air conditioning systems
• Decorative fountains
• Swimming pools
• Physical therapy equipment
• Water systems in hotels, hospitals and nursing homes

Scientists aren't certain how much exposure to the bacteria is needed to cause disease, but some people have developed infections after inhaling contaminated droplets for just a few minutes. And unlike many bacteria, which spread within a small radius, legionella bacteria may be capable of traveling as far as four miles through the air.

Although legionella bacteria primarily spread through aerosolized water droplets, the infection can be transmitted in other ways, including:

• Aspiration. This occurs when liquids accidentally enter your lungs, usually because you cough or choke while drinking. If you aspirate water containing legionella bacteria, you may develop the disease.
• Soil. A few people have contracted Legionnaire's disease after working in the garden or using contaminated potting soil. It's also possible that the disease may spread when earth containing the bacteria is stirred up at large construction sites.

Beating the immune system
Once legionella bacteria enter your lungs, they're surrounded by immune system cells (alveolar macrophages) that normally attack and destroy foreign organisms. But rather than being destroyed by these cells, the legionella bacteria turn them to their advantage. The legionella bacteria enter the macrophages, use them to grow and replicate, and eventually kill them. When the macrophages die, thousands of new bacteria are released into your lungs, worsening symptoms during the first week of the infection and perpetuating the cycle of the disease.

©1998-2009 Mayo Foundation for Medical Education and Research (MFMER). Terms of use.

Not everyone exposed to legionella bacteria becomes sick. You're more likely to develop the infection if you:

• Smoke. Smoking damages the lungs, making you more susceptible to all types of lung infections.
• Have a weakened immune system as a result of HIV/AIDS or certain medications, especially corticosteroids and drugs taken to prevent organ rejection after a transplant.
• Have a chronic lung disease such as emphysema or another serious condition such as diabetes, kidney disease or cancer.
• Are 65 years of age or older.
• Have a job maintaining the cooling towers in air conditioning systems.

Legionnaires' disease is a sporadic and local problem in hospitals and nursing homes, where germs may spread easily and people are vulnerable to infection.

©1998-2009 Mayo Foundation for Medical Education and Research (MFMER). Terms of use.

Legionnaires' disease can lead to a number of life-threatening complications, including:

• Respiratory failure. This occurs when the lungs are no longer able to provide the body with enough oxygen or can't remove enough carbon dioxide from the blood.
• Septic shock. This occurs when a severe, sudden drop in blood pressure reduces blood flow to vital organs, especially the kidneys and brain. The heart tries to compensate by increasing the volume of blood pumped, but the extra workload eventually weakens the heart and reduces blood flow even further.
• Acute kidney failure. This is the sudden loss of your kidneys' ability to perform their main function — eliminate excess fluid and waste material from your blood. When your kidneys lose their filtering ability, dangerous levels of fluid and waste accumulate in your body.

When not treated effectively and promptly, Legionnaires' disease may be fatal, especially if your immune system is weakened by disease or medications.

©1998-2009 Mayo Foundation for Medical Education and Research (MFMER). Terms of use.

Legionnaires' disease is under-reported and underdiagnosed, primarily because special tests are needed to distinguish Legionnaires' disease from other types of pneumonia. To help identify the presence of legionella bacteria quickly, your doctor may use a test that checks your urine for legionella antigens — foreign substances that trigger an immune system response. You may also have one or more of the following:

• Blood tests
• A chest X-ray, which doesn't confirm Legionnaires' disease but can show the extent of infection in your lungs
• Tests on a sample of your sputum or lung tissue
• A CT scan of your brain or a spinal tap (lumbar puncture) if you have neurological symptoms such as confusion or trouble concentrating

©1998-2009 Mayo Foundation for Medical Education and Research (MFMER). Terms of use.

Legionnaires' disease is treated with antibiotics. The sooner therapy is started, the less likely the chance of serious complications or death. Pontiac fever goes away on its own without treatment and causes no lingering problems.

©1998-2009 Mayo Foundation for Medical Education and Research (MFMER). Terms of use.

Outbreaks of Legionnaire's disease are preventable, but it requires meticulous cleaning and disinfection of water systems, pools and spas.

Avoiding smoking is the single most important thing you can do to lower your risk of infection. Smoking increases the chances that you'll develop Legionnaires' disease if you're exposed to legionella bacteria.

©1998-2009 Mayo Foundation for Medical Education and Research (MFMER). Terms of use.